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Review
. 2013 May;95(5):1818-26.
doi: 10.1016/j.athoracsur.2012.11.020. Epub 2013 Apr 6.

Postsurgical intrapericardial adhesions: mechanisms of formation and prevention

Aldo Cannata  1 , Duccio Petrella, Claudio Francesco Russo, Giuseppe Bruschi, Pasquale Fratto, Marcello Gambacorta, Luigi Martinelli
Affiliations
Review

Postsurgical intrapericardial adhesions: mechanisms of formation and prevention

Aldo Cannata et al. Ann Thorac Surg. 2013 May.

Abstract

Postsurgical intrapericardial adhesions are still considered an unavoidable consequence of cardiothoracic operations. They increase the technical difficulty and the risk of reoperations. The pathogenesis of postsurgical adhesions is a multistep process, and the main key players are (1) loss of mesothelial cells, (2) accumulation of fibrin in areas devoid of mesothelial cells, (3) loss of normal pericardial fibrinolysis, and (4) local inflammation. Today, very promising methods to reduce adhesions are available for clinical use. This report reviews the process of formation of adhesions and the methods to prevent them, classified according to the mechanism of action.

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Comment in

  • TachoSil to prevent postoperative pericardial adhesions.
    Hajj-Chahine J, Jayle C, Tomasi J, Corbi P. Hajj-Chahine J, et al. Ann Thorac Surg. 2014 Jan;97(1):378-9. doi: 10.1016/j.athoracsur.2013.06.075. Ann Thorac Surg. 2014. PMID: 24384202 No abstract available.
  • Reply: To PMID 23566646.
    Cannata A, Martinelli L. Cannata A, et al. Ann Thorac Surg. 2014 Jan;97(1):379. doi: 10.1016/j.athoracsur.2013.07.106. Ann Thorac Surg. 2014. PMID: 24384205 No abstract available.

MeSH terms