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Case Reports
. 2013 Apr;140(4):278-81.
doi: 10.1016/j.annder.2013.01.424. Epub 2013 Feb 20.

[Limbic encephalitis: a new paraneoplastic auto-immune manifestation associated with metastatic melanoma?]

[Article in French]
C Becquart  1 , G Ryckewaert, E Desmedt, L Defebvre, E Le Rhun, L Mortier
Affiliations
Case Reports

[Limbic encephalitis: a new paraneoplastic auto-immune manifestation associated with metastatic melanoma?]

[Article in French]
C Becquart et al. Ann Dermatol Venereol. 2013 Apr.

Abstract

Background: Several studies indicate an association between immune-related manifestations and prolonged survival in metastatic melanoma. Limbic encephalitis driven by immune-mediated disorders may also be observed during the course of certain cancers.

Patients and methods: In November 2009, a 60-year-old woman followed up for metastatic melanoma since July 2005 developed rapidly progressive cognitive disorder. Clinical, biological, MRI and electroencephalogram abnormalities resulted in diagnosis of probably paraneoplastic limbic encephalitis in a context of immune-related manifestations although chemotoxicity could not be ruled out. Auto-immunity with hypothyroidism and thrombocytopenia were seen concomitantly.

Discussion: To the best of our knowledge, this is the first reported case of probably paraneoplastic limbic encephalitis associated with melanoma, a new example of an immune-related condition associated with prolonged survival in metastatic melanoma.

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