doi: 10.1039/c3mb70081j.
Epub 2013 Apr 9.
Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus
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- PMID: 23567908
- DOI: 10.1039/c3mb70081j
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Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus
Mol Biosyst.
2013 Jun.
Abstract
The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2-3, respectively.
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