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Review
. 2013 Mar 15;112(6):969-76; discussion 976.
doi: 10.1161/CIRCRESAHA.112.300567.

Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model?

Björn C Knollmann  1
Affiliations
Review

Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model?

Björn C Knollmann. Circ Res. .

Abstract

This article reviews the strengths and limitations of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) as models of cardiac arrhythmias. Specifically, the article attempts to answer the following questions: Which clinical arrhythmias can be modeled by iPSC-CM? How well can iPSC-CM model adult ventricular myocytes? What are the strengths and limitations of published iPSC-CM arrhythmia models? What new mechanistic insight has been gained? What is the evidence that would support using iPSC-CM to personalize antiarrhythmic drug therapy? The review also discusses the pros and cons of using the iPSC-CM technology for modeling specific genetic arrhythmia disorders, such as long QT syndrome, Brugada Syndrome, or Catecholaminergic Polymorphic Ventricular Tachycardia.

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Figures

Figure 1
Figure 1
Comparison of cellular action potential (AP) of iPSC-CM derived either from a healthy individual (Control) or from a CPVT patient homozygous for the CASQ2-D307H mutation (CPVT). Image reproduced from Figure 7 in the article by Novak et al. Note the profound AP prolongation exhibited by the CPVT iPSC-CM.
Figure 2
Figure 2
Journal impact factor of published iPSC-CM arrhythmia models.
See this image and copyright information in PMC

Comment on

References

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