Intestinal alkaline phosphatase prevents metabolic syndrome in mice
- PMID: 23569246
- PMCID: PMC3637741
- DOI: 10.1073/pnas.1220180110
Intestinal alkaline phosphatase prevents metabolic syndrome in mice
Abstract
Metabolic syndrome comprises a cluster of related disorders that includes obesity, glucose intolerance, insulin resistance, dyslipidemia, and fatty liver. Recently, gut-derived chronic endotoxemia has been identified as a primary mediator for triggering the low-grade inflammation responsible for the development of metabolic syndrome. In the present study we examined the role of the small intestinal brush-border enzyme, intestinal alkaline phosphatase (IAP), in preventing a high-fat-diet-induced metabolic syndrome in mice. We found that both endogenous and orally supplemented IAP inhibits absorption of endotoxin (lipopolysaccharides) that occurs with dietary fat, and oral IAP supplementation prevents as well as reverses metabolic syndrome. Furthermore, IAP supplementation improves the lipid profile in mice fed a standard, low-fat chow diet. These results point to a potentially unique therapy against metabolic syndrome in at-risk humans.
Conflict of interest statement
The authors declare no conflict of interest.
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Comment in
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Inflammation: Intestinal-type alkaline phosphatase--a new therapeutic weapon?Nat Rev Endocrinol. 2013 Jul;9(7):379. doi: 10.1038/nrendo.2013.95. Epub 2013 Apr 23. Nat Rev Endocrinol. 2013. PMID: 23609332 No abstract available.
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