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. 2013 Sep 1;31(25):3158-61.
doi: 10.1200/JCO.2012.48.3826. Epub 2013 Apr 8.

Phase III clinical trials that integrate treatment and biomarker evaluation

Boris Freidlin  1 , Zhuoxin Sun, Robert Gray, Edward L Korn
Affiliations

Phase III clinical trials that integrate treatment and biomarker evaluation

Boris Freidlin et al. J Clin Oncol. .
No abstract available

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Conflict of interest statement

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.

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References

    1. Simon R, Maitournam A. Evaluating the efficiency of targeted designs for randomized clinical trials. Clinical Cancer Res. 2004;10:6759–6763. - PubMed
    1. Freidlin B, McShane LM, Polley MY, et al. Randomized phase II trial designs with biomarkers. J Clin Oncol. 2012;30:3304–3309. - PMC - PubMed
    1. Mandrekar SJ, Sargent DJ. Clinical trial designs for predictive biomarker validation: Theoretical considerations and practical challenges. J Clin Oncol. 2009;27:4027–4034. - PMC - PubMed
    1. Freidlin B, McShane LM, Korn EL. Randomized clinical trials with biomarkers: Design issues. J Natl Cancer Inst. 2010;102:152–160. - PMC - PubMed
    1. Simon R. Clinical trials for predictive medicine. Stat Med. 2012;31:3031–3040. - PubMed

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