Intraductal papilloma of the breast in association with preoncogenic gene of breast cancer

Abstract

We reported a case of an African American woman who went to the hospital with palpable right breast lump with bloody nipple discharge at University of Texas Medical Branch at Galveston. The modalities of breast imagings included mammography and ultrasonography. The method used for viral identification was Linear Array HPV genotyping test. Intraductal papilloma revealed as high density tubular or rounded lobular masses with partially circumscribed, obscured margins and clustered punctate microcalcifications on mammograms. Ultrasound showed as intraductal masses with dilated ducts. The core biopsy demonstrated duct filled with papillary lesion and post excision revealed intraductal papilloma. HPV DNA types 16, 33, 58 and 71 were detected after use of Linear Array HPV genotyping test.

Keywords: Breast cancer; Human papilloma virus; Mammography; Preoncogenic gene; Ultrasound.

Figure 1.. Mammograms of mediolateral (A) and caniocraudal (B).

It showed a slightly high density tubular and rounded lobular masse with partially circumscribed, obscured margins, measuring 50 mm almost involving the entire lower outer quadrant of right breast.

Figure 2.. Right magnification views.

Mediolateral (A) and craniocaudal (B) demonstrated multiple clusters of punctate microcalcifications at lower outer quadrant anterior and middle depth.

Figure 3.. Ultrasonography revealed numerous intraductal lesions with dimention subcentimeter at the site of mammographic findings.

Figure 4.. Photomicrograph of the intraductal papillary lesion showing multiple fibrovascular core and epithelial proliferation.

Figure 5.. HPV genotyping was positive for genotypes 16, 33, 58, and 71.