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. 2011 Dec;1(6):448-51.
doi: 10.1016/S2221-1691(11)60098-1.

Inhibition of Ehrlich ascites carcinoma by Manilkara zapota L. stem bark in Swiss albino mice

M Abu Osman  1 , M Mamunur Rashid, M Abdul Aziz, M Rowshahul Habib, M Rezaul Karim
Affiliations

Inhibition of Ehrlich ascites carcinoma by Manilkara zapota L. stem bark in Swiss albino mice

M Abu Osman et al. Asian Pac J Trop Biomed. 2011 Dec.

Abstract

Objective: To evaluate the antitumor activity of Manilkara zapota (M. zapota) L. stem bark against Ehrlich ascites carcinoma (EAC) in Swiss albino mice.

Methods: The in vivo antitumour activity of the ethyl acetate extract of stem bark of M. zapota L. (EASM) was evaluated at 50, 100 and 200 mg/kg bw against EAC using mean survival time. After administration of the extract of M. zapota, viable EAC cell count and body weight in the EAC tumour hosts were observed. The animal was also observed for improvement in the haematological parameters (e.g., heamoglobin content, red and white blood cells count and differential cell count) after EASM treatment.

Results: Intraperitoneal administration of EASM reduced viable EAC cells, increased the survival time, and restored altered haematological parameters. Significant efficacy was observed for EASM at 100 mg/kg dose (P<0.05).

Conclusions: It can be concluded that the ethyl acetate extract of stem bark of M. zapota L. possesses significant antitumour activity.

Keywords: Antitumour activity; Ehrlich ascites carcinoma; Haematological parameter; Manilkara zapota; Stem bark.

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Conflict of interest statement

Conflict of interest statement: We declare that we have no conflict of interest.

Figures

Figure 1.
Figure 1.. Effect of EASM on EAC cell bearing mice.
A: Viable EAC cells on the 6th day after tumor cell inoculation; B: Mean survival time; C: % increase in life span; D: Body weight gain on the 14th day. Data are expressed as mean ± SEM (n = 6). *P<0.05, between EAC control and EASM-treated group.
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