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. 2012 Oct;2(10):782-6.
doi: 10.1016/S2221-1691(12)60229-9.

Pharmacognostical, phytochemical and pharmacological evaluation for the antipyretic effect of the seeds of Saraca asoca Roxb

S Sasmal  1 , S Majumdar, M Gupta, A Mukherjee, P K Mukherjee
Affiliations

Pharmacognostical, phytochemical and pharmacological evaluation for the antipyretic effect of the seeds of Saraca asoca Roxb

S Sasmal et al. Asian Pac J Trop Biomed. 2012 Oct.

Abstract

Objective: To conduct a systemic evaluation of the medicinal value of seeds which include macroscopic and microscopic characterization, physiochemical evaluation, preliminary phytochemical screening and experimental antipyretic activity.

Methods: Saraca asoca seed was studied for pharmacognostical, phytochemical and other recommended methods for standardizations. Also, the acetone extract of the seeds was evaluated for acute toxicity study and antipyretic activity using Brewer's yeast induced pyrexia in Wistar rats at oral doses of 300 mg/kg and 500 mg/kg.

Results: After phytochemical screening, the acetone extract showed the presence of saponin, tannins and flavonoids which inhibit pyrexia. The therapeutic efficacy achieved at both the dose levels of the research drug and standard drug aspirin (100 mg/kg) showed significant (P<0.01) antipyretic activity when compared to the control group. The highly significant antipyretic effect exhibited at the dose of 500 mg/kg was also found to be sustainable in nature.

Conclusions: The antipyretic effect of the acetone extract showed significant results in rats at the dose of 500 mg/kg after following the standard pharmacognostical and phytochemical methods.

Keywords: Acetone extract; Antipyretic; Pharmacognosy; Saraca asoca; Seed.

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Conflict of interest statement

Conflict of interest statement: We declare that we have no conflict of interest.

Figures

Figure 1.
Figure 1.. T.S. of S. asoca seed.
A: Starch grain; B: Vessel; C: Crystal
Figure 2.
Figure 2.. Percentage reduction of rectal temperature of aspirin and acetone extracts of the seeds of Saraca asoca.
Asp: Aspirin; AE: Acetone extract.
See this image and copyright information in PMC

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