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. 2013 Jun;57(6):2882-6.
doi: 10.1128/AAC.00261-13. Epub 2013 Apr 9.

Analysis of anti-Clostridium difficile activity of thuricin CD, vancomycin, metronidazole, ramoplanin, and actagardine, both singly and in paired combinations

Harsh Mathur  1 , Paula M O'Connor, Colin Hill, Paul D Cotter, R Paul Ross
Affiliations

Analysis of anti-Clostridium difficile activity of thuricin CD, vancomycin, metronidazole, ramoplanin, and actagardine, both singly and in paired combinations

Harsh Mathur et al. Antimicrob Agents Chemother. 2013 Jun.

Abstract

Due to the ongoing problem of recurrence of Clostridium difficile-associated diarrhea following antibiotic treatment, there is an urgent need for alternative treatment options. We assessed the MICs of five antimicrobials singly and in combinations against a range of C. difficile clinical isolates. Ramoplanin-actagardine combinations were particularly effective, with partial synergistic/additive effects observed against 61.5% of C. difficile strains tested.

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References

    1. Vollaard EJ, Clasener HA. 1994. Colonization resistance. Antimicrob. Agents Chemother. 38:409–414 - PMC - PubMed
    1. Shanahan F. 2002. The host-microbe interface within the gut. Best Pract. Res. Clin. Gastroenterol. 16:915–931 - PubMed
    1. O'Hara AM, Shanahan F. 2006. The gut flora as a forgotten organ. EMBO Rep. 7:688–693 - PMC - PubMed
    1. Blaser MJ. 2011. Antibiotic overuse: stop killing the beneficial flora. Nature 476:393–394 - PubMed
    1. Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR. 2007. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel disease. Proc. Natl. Acad. Sci. U. S. A. 104:13780–13785 - PMC - PubMed

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