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Controlled Clinical Trial
. 2013;6(2):124-33.
doi: 10.1159/000350664. Epub 2013 Apr 4.

Factors related with adiponectinemia in obese and normal-weight women and with its variation in weight loss programs

José Silva-Nunes  1 , Ana Oliveira, Leone Duarte, Margarida Barradas, Alice Melão, Miguel Brito, Luisa Veiga
Affiliations
Controlled Clinical Trial

Factors related with adiponectinemia in obese and normal-weight women and with its variation in weight loss programs

José Silva-Nunes et al. Obes Facts. 2013.

Abstract

Objective: To assess different factors influencing adiponectinemia in obese and normal-weight women; to identify factors associated with the variation (Δ) in adiponectinemia in obese women following a 6-month weight loss program, according to surgical/non-surgical interventions.

Methods: We studied 100 normal-weight women and 112 obese premenopausal women; none of them was on any medical treatment. Women were characterized for anthropometrics, daily macronutrient intake, smoking status, contraceptives use, adiponectin as well as IL-6 and TNF-α serum concentrations.

Results: Adiponectinemia was lower in obese women (p < 0.001), revealing an inverse association with waist-to-hip ratio (p < 0.001; r = -0.335). Normal-weight women presented lower adiponectinemia among smokers (p = 0.041); body fat, waist-to-hip ratio, TNF-α levels, carbohydrate intake, and smoking all influence adiponectinemia (r(2) = 0.436). After weight loss interventions, a significant modification in macronutrient intake occurs followed by anthropometrics decrease (chiefly after bariatric procedures) and adiponectinemia increase (similar after surgical and non-surgical interventions). After bariatric intervention, Δ adiponectinemia was inversely correlated to Δ waist circumference and Δ carbohydrate intake (r(2) = 0.706).

Conclusion: Anthropometrics, diet, smoking, and TNF-α levels all influence adiponectinemia in normal-weight women, although explaining less than 50% of it. In obese women, anthropometrics modestly explain adiponectinemia. Opposite to non-surgical interventions, after bariatric surgery adiponectinemia increase is largely explained by diet composition and anthropometric changes.

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Figures

Fig. 1
Fig. 1
Adiponectin levels in obese and normal-weight women according to smoking status.
Fig. 2
Fig. 2
Variation in adiponectin circulating levels of obese women after 6 months in weight loss programs, according to surgical or non-surgical interventions.
See this image and copyright information in PMC

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