doi: 10.1126/scisignal.2003945.
Neuregulin-1 type I: a hidden power within Schwann cells for triggering peripheral nerve remyelination
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- PMID: 23572145
- DOI: 10.1126/scisignal.2003945
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Neuregulin-1 type I: a hidden power within Schwann cells for triggering peripheral nerve remyelination
Sci Signal.
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Abstract
Physiological interactions and reciprocal signaling between axons and Schwann cells play critical roles in nerve development and survival. Axonally derived neuregulin-1 (NRG-1) type III is an essential modulator of Schwann cells during development, nerve repair, and remyelination. A recent report demonstrates an unexpected regulatory role for Schwann cell-derived NRG-1 type I in Schwann cell plasticity and remyelination after peripheral nerve injury. Specifically expressed in Schwann cells at critical time points after nerve injury, this isoform of NRG-1 emerges as a driving force for regeneration and remyelination programs.
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