Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:2013:148673.
doi: 10.1155/2013/148673. Epub 2013 Mar 13.

The role of vitamin d deficiency in the incidence, progression, and complications of type 1 diabetes mellitus

Marlene Chakhtoura  1 , Sami T Azar
Affiliations

The role of vitamin d deficiency in the incidence, progression, and complications of type 1 diabetes mellitus

Marlene Chakhtoura et al. Int J Endocrinol. 2013.

Abstract

The "nonclassic" role of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has been recently widely recognized. In type 1 diabetes mellitus (T1D), it plays an immunomodulatory role through the vitamin D receptor (VDR) present on pancreatic and immune cells. Specific VDR allelic variants have been associated with T1D in many countries. Furthermore, vitamin D deficiency has been prevalent in T1D, and the seasonal and latitude variability in the incidence of T1D can be partly explained by the related variability in vitamin D level. In fact, retrospective studies of vitamin D supplementation during pregnancy or infancy showed a lower incidence of T1D. We will review the different mechanisms of the vitamin D protective effect against insulitis and present the available data on the role of vitamin D deficiency in the control, progression, and complications of T1D.

PubMed Disclaimer

Figures

Figure 1
Figure 1
See this image and copyright information in PMC

References

    1. Harrison LC, Honeyman MC, Morahan G, et al. Type 1 diabetes: lessons for other autoimmune diseases? Journal of Autoimmunity. 2008;31(3):306–310. - PubMed
    1. Craig ME, Hattersley A, Donaghue K. Definition, epidemiology and classification of diabetes in children and adolescents. Pediatric Diabetes. 2009;7(10, supplement 12):3–12. - PubMed
    1. Lammi N, Taskinen O, Moltchanova E, et al. A high incidence of type 1 diabetes and an alarming increase in the incidence of type 2 diabetes among young adults in Finland between 1992 and 1996. Diabetologia. 2007;50(7):1393–1400. - PubMed
    1. Forlenza GP, Rewers M. The epidemic of type 1 diabetes: what is it telling us? Current Opinion in Endocrinology, Diabetes and Obesity. 2011;18(4):248–251. - PubMed
    1. Moroni L, Bianchi I, Lleo A. Geoepidemiology, gender and autoimmune disease. Autoimmunity Reviews. 2012;11:A386–A392. - PubMed

LinkOut - more resources