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. 2013 Feb;13(1):88-92.
doi: 10.12816/0003200. Epub 2013 Feb 27.

Ankle brachial index in children with steroid-resistant nephrotic syndrome

Sheren M Mohamed  1 , Abdelazem Elmazary, Hany T Taha
Affiliations

Ankle brachial index in children with steroid-resistant nephrotic syndrome

Sheren M Mohamed et al. Sultan Qaboos Univ Med J. 2013 Feb.

Abstract

Objectives: This study aimed to assess the ankle brachial index (ABI) as a predictor of peripheral arterial diseases (PAD) in children with steroid-resistant nephrotic syndrome (NS).

Methods: Twenty children (11 males and 9 females) attending the Pediatric Nephrology Outpatient Clinic of El-Minia University Hospital, Egypt, were enrolled in this study. Their age ranged between 5 and 15 years with a mean of 10.75 ± 3.31 years. They had proteinuria and were dependent on steroid therapy. Twenty healthy age- and sex-matched children served as a control group. All patients and controls underwent a thorough history-taking and clinical examination. All subjects in the study underwent laboratory investigations, including a urine analysis (24-hour test for protein in urine, and levels of serum urea and creatinine, triglycerides, and cholesterol). A renal biopsy was done to diagnose the children's histopathological type of NS. A Doppler study was done to determine patients' ABI.

Results: ABI was significantly higher in the patient group than in the control group (P <0.0001). There was a negative correlation between ABI and duration of treatment (r value = 0.77 and P <0.001).

Conclusion: ABI is simple non-invasive manoeuvre that can reliably assess arterial stiffness as an early predictor of atherosclerosis in nephrotic patients with long duration of both illness and steroid therapy.

Keywords: Ankle brachial index; Children; Egypt; Nephrotic syndrome; Steroid resistant.

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References

    1. Anderson S, Komers R, Brenner BM. Renal and Systemic Manifestations of Glomerular Disease. In: Brenner BM, editor. The Kidney. 8th ed. Philadelphia: Saunders Elsevier; 2008. pp. 925–50.
    1. Saland JM, Ginsberg H, Fisher EA. Dyslipidemia in pediatric renal disease: Epidemiology, pathophysiology, and management. Curr Opin Pediatr. 2002;14:197–204. - PubMed
    1. McDermott MM, Criqui MH, Liu K, Guralnik JM, Greenland P, Martin GJ, et al. Lower ankle/brachial index, as calculated by averaging the dorsalis pedis and posterior tibial arterial pressures, and association with leg functioning in peripheral arterial disease. J Vasc Surg. 2000;32:1164–71. - PubMed
    1. Hogg RJ, Portman RJ, Milliner D, Lemley KV, Eddy A, Ingelfinger J. Evaluation and management of proteinuria and nephrotic syndrome in children: Recommendations from a pediatric nephrology panel established at the National Kidney Foundation conference on proteinuria, albuminuria, risk, assessment, detection, and elimination (PARADE) Pediatrics. 2000;105:1242–9. - PubMed
    1. Vowden P, Vowden K. Doppler assessment and ABPI: Interpretation in the management of leg ulceration. From: www.worldwidewounds.com/wowden/doppler-assessment-ABI.html Accessed: Mar 2001.

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