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. 1990 Apr 23;514(1):135-40.
doi: 10.1016/0006-8993(90)90445-h.

Immunoreactive interleukin-1 beta localization in the rat forebrain

R M Lechan  1 , R Toni, B D Clark, J G Cannon, A R Shaw, C A Dinarello, S Reichlin
Affiliations

Immunoreactive interleukin-1 beta localization in the rat forebrain

R M Lechan et al. Brain Res. .

Abstract

To determine whether the cytokine, interleukin-1 beta, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1 beta. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1 beta is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

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