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. 2013:7:637-41.
doi: 10.2147/OPTH.S39796. Epub 2013 Mar 31.

Adjuvant corneal crosslinking to prevent hyperopic LASIK regression

Ioannis M Aslanides  1 , Achyut N Mukherjee
Affiliations

Adjuvant corneal crosslinking to prevent hyperopic LASIK regression

Ioannis M Aslanides et al. Clin Ophthalmol. 2013.

Abstract

Purpose: To report the long term outcomes, safety, stability, and efficacy in a pilot series of simultaneous hyperopic laser assisted in situ keratomileusis (LASIK) and corneal crosslinking (CXL).

Method: A small cohort series of five eyes, with clinically suboptimal topography and/or thickness, underwent LASIK surgery with immediate riboflavin application under the flap, followed by UV light irradiation. Postoperative assessment was performed at 1, 3, 6, and 12 months, with late follow up at 4 years, and results were compared with a matched cohort that received LASIK only.

Results: The average age of the LASIK-CXL group was 39 years (26-46), and the average spherical equivalent hyperopic refractive error was +3.45 diopters (standard deviation 0.76; range 2.5 to 4.5). All eyes maintained refractive stability over the 4 years. There were no complications related to CXL, and topographic and clinical outcomes were as expected for standard LASIK.

Conclusion: This limited series suggests that simultaneous LASIK and CXL for hyperopia is safe. Outcomes of the small cohort suggest that this technique may be promising for ameliorating hyperopic regression, presumed to be biomechanical in origin, and may also address ectasia risk.

Keywords: CXL.

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Figures

Figure 1
Figure 1
Application of riboflavin to the stromal bed immediately following hyperopic LASIK. Abbreviation: LASIK, laser assisted in situ keratomileusis.
Figure 2
Figure 2
Attempted vs achieved refractive outcomes in hyperopic LASIK with simultaneous corneal crosslinking. Abbreviations: LASIK, laser assisted in situ keratomileusis; D, diopters.
Figure 3
Figure 3
Stability of refractive correction in (A) hyperopic LASIK with simultaneous corneal crosslinking (LASIK-CXL); and (B) a matched control group. Abbreviations: LASIK, laser assisted in situ keratomileusis; CXL, crosslinking; SD, standard deviation; D, diopter.
See this image and copyright information in PMC

References

    1. Pallikaris IG, Kymionis GD, Astyrakakis NI. Corneal ectasia induced by laser in situ keratomileusis. J Cataract Refract Surg. 2001;27(11):1796–1802. - PubMed
    1. Binder PS. Analysis of ectasia after laser in situ keratomileusis: risk factors. J Cataract Refract Surg. 2007;33(9):1530–1538. - PubMed
    1. Randleman JB, Woodward M, Lynn MJ, Stulting RD. Risk assessment for ectasia after corneal refractive surgery. Ophthalmology. 2008;115(1):37–50. - PubMed
    1. Settas G, Settas C, Minos E, Yeung IY. Photorefractive keratectomy (PRK) versus laser assisted in situ keratomileusis (LASIK) for hyperopia correction. Cochrane Database Syst Rev. 2012;6:CD007112. - PMC - PubMed
    1. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135(5):620–627. - PubMed

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