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Meta-Analysis
. 2013;8(4):e60178.
doi: 10.1371/journal.pone.0060178. Epub 2013 Apr 5.

hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma among East Asians: a meta-analysis

Wenjun Wang  1 , Shuangsuo Dang, Yaping Li, Mingzhu Sun, Xiaoli Jia, Rui Wang, Jingkun Liu
Affiliations
Meta-Analysis

hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma among East Asians: a meta-analysis

Wenjun Wang et al. PLoS One. 2013.

Abstract

Background: The hOGG1 gene encodes a DNA glycosylase enzyme responsible for DNA repair. The Ser326Cys polymorphism in this gene may influence its repair ability and thus plays a role in carcinogenesis. Several case-control studies have been conducted on this polymorphism and its relationship with the risk of hepatocellular carcinoma (HCC) among East Asians. However, their results are inconsistent.

Methods: We performed a meta-analysis of published case-control studies assessing the association of the hOGG1 Ser326Cys polymorphism with HCC risk among East Asians. PubMed, EMBASE, SCI, BIOSIS, CNKI and WanFang databases were searched. A random-effect model was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). Analyses were conducted for additive, dominant and recessive genetic models.

Results: Eight studies were identified involving 2369 cases and 2442 controls assessing the association of the hOGG1 Ser326Cys polymorphism with HCC risk among East Asians. Applying a dominant genetic model, only in the Chinese population, the Cys allele was significantly associated with increased risk of HCC (OR 1.56, 95% CI 1.12-2.17). However, two studies influenced this finding according to sensitivity analysis. Furthermore, considerable heterogeneity and bias existed among Chinese studies.

Conclusion: There is limited evidence to support that the hOGG1 Ser326Cys polymorphism is associated with HCC risk among East Asians. Well-designed and large-sized studies are required to determine this relationship.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow diagram of the study selection process.
Figure 2
Figure 2. Forest plots for the hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma using the dominant genetic model (Ser/Cys+Cys/Cys vs. Ser/Ser).
The squares and horizontal lines correspond to the study specific odds ratios and 95% confidence intervals. The diamond represents the summary odds ratio and 95% confidence interval.
Figure 3
Figure 3. Forest plots for the hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma using the additive genetic model (Cys/Cys vs. Ser/Ser).
The squares and horizontal lines correspond to the study specific odds ratios and 95% confidence intervals. The diamond represents the summary odds ratio and 95% confidence interval.
Figure 4
Figure 4. Forest plots for the hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma using the recessive genetic model (Cys/Cys vs. Ser/Cys+Ser/Ser).
The squares and horizontal lines correspond to the study specific odds ratios and 95% confidence intervals. The diamond represents the summary odds ratio and 95% confidence interval.
See this image and copyright information in PMC

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