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Meta-Analysis
. 2013;8(4):e60178.
doi: 10.1371/journal.pone.0060178. Epub 2013 Apr 5.

hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma among East Asians: a meta-analysis

Wenjun Wang  1 , Shuangsuo Dang, Yaping Li, Mingzhu Sun, Xiaoli Jia, Rui Wang, Jingkun Liu
Affiliations
Meta-Analysis

hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma among East Asians: a meta-analysis

Wenjun Wang et al. PLoS One. 2013.

Abstract

Background: The hOGG1 gene encodes a DNA glycosylase enzyme responsible for DNA repair. The Ser326Cys polymorphism in this gene may influence its repair ability and thus plays a role in carcinogenesis. Several case-control studies have been conducted on this polymorphism and its relationship with the risk of hepatocellular carcinoma (HCC) among East Asians. However, their results are inconsistent.

Methods: We performed a meta-analysis of published case-control studies assessing the association of the hOGG1 Ser326Cys polymorphism with HCC risk among East Asians. PubMed, EMBASE, SCI, BIOSIS, CNKI and WanFang databases were searched. A random-effect model was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). Analyses were conducted for additive, dominant and recessive genetic models.

Results: Eight studies were identified involving 2369 cases and 2442 controls assessing the association of the hOGG1 Ser326Cys polymorphism with HCC risk among East Asians. Applying a dominant genetic model, only in the Chinese population, the Cys allele was significantly associated with increased risk of HCC (OR 1.56, 95% CI 1.12-2.17). However, two studies influenced this finding according to sensitivity analysis. Furthermore, considerable heterogeneity and bias existed among Chinese studies.

Conclusion: There is limited evidence to support that the hOGG1 Ser326Cys polymorphism is associated with HCC risk among East Asians. Well-designed and large-sized studies are required to determine this relationship.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow diagram of the study selection process.
Figure 2
Figure 2. Forest plots for the hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma using the dominant genetic model (Ser/Cys+Cys/Cys vs. Ser/Ser).
The squares and horizontal lines correspond to the study specific odds ratios and 95% confidence intervals. The diamond represents the summary odds ratio and 95% confidence interval.
Figure 3
Figure 3. Forest plots for the hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma using the additive genetic model (Cys/Cys vs. Ser/Ser).
The squares and horizontal lines correspond to the study specific odds ratios and 95% confidence intervals. The diamond represents the summary odds ratio and 95% confidence interval.
Figure 4
Figure 4. Forest plots for the hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma using the recessive genetic model (Cys/Cys vs. Ser/Cys+Ser/Ser).
The squares and horizontal lines correspond to the study specific odds ratios and 95% confidence intervals. The diamond represents the summary odds ratio and 95% confidence interval.
See this image and copyright information in PMC

References

    1. Ferlay J, Shin H, Bray F, Forman D, Mathers C, et al. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893–2917. - PubMed
    1. Venook AP, Papandreou C, Furuse J, de Guevara LL (2010) The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective. Oncologist 15 Suppl 45–13. - PubMed
    1. Donato F, Tagger A, Gelatti U, Parrinello G, Boffetta P, et al. (2002) Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women. Am J Epidemiol 155: 323–331. - PubMed
    1. El-Serag H (2011) Hepatocellular carcinoma. N Engl J Med 365: 1118–1127. - PubMed
    1. El-Serag H, Tran T, Everhart J (2004) Diabetes increase the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology 126: 460–468. - PubMed

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