Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:2013:641570.
doi: 10.1155/2013/641570. Epub 2013 Mar 12.

Implementing the brazilian database on orofacial clefts

Isabella Lopes Monlleó  1 , Marshall Ítalo Barros Fontes, Erlane Marques Ribeiro, Josiane de Souza, Gabriela Ferraz Leal, Têmis Maria Félix, Agnes Cristina Fett-Conte, Bruna Henrique Bueno, Luis Alberto Magna, Peter Anthony Mossey, Vera Gil-da Silva-Lopes
Affiliations

Implementing the brazilian database on orofacial clefts

Isabella Lopes Monlleó et al. Plast Surg Int. 2013.

Abstract

Background. High-quality clinical and genetic descriptions are crucial to improve knowledge of orofacial clefts and support specific healthcare polices. The objective of this study is to discuss the potential and perspectives of the Brazilian Database on Orofacial Clefts. Methods. From 2008 to 2010, clinical and familial information on 370 subjects was collected by geneticists in eight different services. Data was centrally processed using an international system for case classification and coding. Results. Cleft lip with cleft palate amounted to 198 (53.5%), cleft palate to 99 (26.8%), and cleft lip to 73 (19.7%) cases. Parental consanguinity was present in 5.7% and familial history of cleft was present in 26.3% subjects. Rate of associated major plus minor defects was 48% and syndromic cases amounted to 25% of the samples. Conclusions. Overall results corroborate the literature. Adopted tools are user friendly and could be incorporated into routine patient care. The BDOC exemplifies a network for clinical and genetic research. The data may be useful to develop and improve personalized treatment, family planning, and healthcare policies. This experience should be of interest for geneticists, laboratory-based researchers, and clinicians entrusted with OC worldwide.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Map of Brazil showing localization of cities and sites participating in the Brazilian database on orofacial clefts (BDOC).
Figure 2
Figure 2
A summary of the process of recording cases through the Brazilian database on orofacial clefts (BDOC). Please refer to text for details.
Figure 3
Figure 3
Distribution of minor defects according to anatomic region between nonsyndromic and syndromic cases.
Figure 4
Figure 4
Distribution of major defects according to anatomic region among syndromic cases.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Dixon MJ, Marazita ML, Beaty TH, Murray JC. Cleft lip and palate: understanding genetic and environmental influences. Nature Reviews Genetics. 2011;12(3):167–178. - PMC - PubMed
    1. Mossey PA, Little J, Munger RG, Dixon MJ, Shaw WC. Cleft lip and palate. The Lancet. 2009;374(9703):1773–1785. - PubMed
    1. Mossey PA, Shaw WC, Munger RG, Murray JC, Murthy J, Little J. Global oral health inequalities: challenges in the prevention and management of orofacial clefts and potential solutions. Advances in Dental Research. 2011;23:247–248. - PMC - PubMed
    1. Luijsterburg AJM, Vermeij-Keers C. Ten years recording common oral clefts with a new descriptive system. The Cleft Palate-Craniofacial Journal. 2011;48(2):173–182. - PubMed
    1. Shprintzen RJ, Siegel-Sadewitz VL, Amato J, Goldberg RB. Anomalies associated with cleft lip, cleft palate, or both. American Journal of Medical Genetics. 1985;20(4):585–595. - PubMed

LinkOut - more resources