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. 2014 Mar;66(2):251-7.
doi: 10.1007/s10616-013-9563-5. Epub 2013 Apr 12.

Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats

Gokhan Bayramoglu  1 , Hakan Senturk, Aysegul Bayramoglu, Mustafa Uyanoglu, Suat Colak, Ayse Ozmen, Durdane Kolankaya
Affiliations

Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats

Gokhan Bayramoglu et al. Cytotechnology. 2014 Mar.

Abstract

Little is known about the protective effects of carvacrol on the symptoms of streptozotocin induced diabetes in rats. Hence, this present study was designed to evaluate the protective effect of the strong antioxidant, carvacrol, on the symptoms of streptozotocin induced diabetes in rats. Carvacrol at the doses of 25 and 50 mg/kg body weight were orally administered to diabetic rats for a period of 7 days after the onset of diabetes. Food-water intake and body weight changes were daily recorded. Biochemical parameters such as serum glucose, insulin, total cholesterol, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase were measured. Although treatment of diabetic rats with oral administration of carvacrol resulted in a slight reduction in serum glucose level and significant reduction in serum total cholesterol, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase in comparison with diabetic control rats, there were no significant differences in serum insulin levels, food-water intake values and body weight changes. Despite the inadequacy of carvacrol on diabetes treatments, it was determined to have at least a partially protective role on liver enzymes.

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Figures

Fig. 1
Fig. 1
Chemical formula of carvacrol
See this image and copyright information in PMC

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