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. 2013 Apr;28(4):614-9.
doi: 10.3346/jkms.2013.28.4.614. Epub 2013 Mar 27.

Clinical characteristics of 75 patients with leukemia cutis

Yeon Soo Kang  1 , Hei Sung Kim, Hyun Jeong Park, Jun Young Lee, Hyung Ok Kim, Baik Kee Cho, Young Min Park
Affiliations

Clinical characteristics of 75 patients with leukemia cutis

Yeon Soo Kang et al. J Korean Med Sci. 2013 Apr.

Abstract

Leukemia cutis (LC) is defined as a neoplastic leukocytic infiltration of the skin. Few clinical studies are available on recent trends of LC in Korea. The purpose of this study was to analyze the clinical features and prognosis of LC in Korea and to compare findings with previous studies. We performed a retrospective study of 75 patients with LC and evaluated the patients' age and sex, clinical features and skin lesion distribution according to the type of leukemia, interval between the diagnosis of leukemia and the development of LC, and prognosis. The male to female ratio was 2:1, and the mean age at diagnosis was 37.6 yr. The most common cutaneous lesions were nodules. The most commonly affected site was the extremities in acute myelocytic leukemia and chronic myelocytic leukemia except for acute lymphocytic leukemia. Compared with previous studies, there was an increasing tendency in the proportion of males and nodular lesions, and LC most often occurred in the extremities. The prognosis of LC was still poor within 1 yr, which was similar to the results of previous studies. These results suggest that there is a difference in the clinical characteristics and predilection sites according to type of leukemia.

Keywords: Clinical Characteristics; Leukemia Cutis; Prognosis.

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Figures

Fig. 1
Fig. 1
Gross manifestation on face. (A) Asymptomatic, multiple, variable-sized, erythematous papules on the face. (B) Painful, oozing, erythematous, erosive patches on the cheek. (C) Tender, crusted plaque on the chin.
Fig. 2
Fig. 2
Gross skin lesions on the trunk or extremities. (A) Multiple, erythematous nodules on the trunk. (B) Multiple, erythematous nodules on the whole body. (C) Pruritic, erythematous papules on both extremities. (D) Solitary, reddish-brown mass on the ankle.
See this image and copyright information in PMC

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MeSH terms