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. 2013 Apr;3(4):384-7.
doi: 10.1158/2159-8290.CD-13-0042.

Colorectal cancer: looking for answers in the microbiota

Christian Jobin  1
Affiliations

Colorectal cancer: looking for answers in the microbiota

Christian Jobin. Cancer Discov. 2013 Apr.

Abstract

At a simplistic level, colorectal cancer arises from mutations in various proto-oncogenes and tumor suppressor genes. Aside from genetically inherited factors, environmental, lifestyle, and dietary habits have all been identified as risk agents promoting mutational events leading to the development of colorectal cancer. This "In Focus" presents evidence that the intestinal endogenous bacterial community represents a risk factor for the development of colorectal cancer.

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Figures

Figure 1
Figure 1
Environmental factors such as diet, inflammation, stress influence microbial composition and cause microbial dysbiosis. Expansion of cancer promoting bacteria with procarcinognic activities (toxin, metabolites) promotes epithelial cell DNA damage, which in conjunction with host responses (cytokines, DNA damaging products) from the underlining tissues, foster dyslastic events and cancer progression.
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