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Editorial
. 2013 Apr 12;112(8):1091-3.
doi: 10.1161/CIRCRESAHA.113.301247.

Hungry for more: autophagy in the pathogenesis of pulmonary arterial hypertension

Dustin R Fraidenburg, Jason X-J Yuan
Editorial

Hungry for more: autophagy in the pathogenesis of pulmonary arterial hypertension

Dustin R Fraidenburg et al. Circ Res. .
No abstract available

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Figures

Figure 1
Figure 1. Proposed role of autophagy in BMPR-II downreglation in PAH
Decreased BMPR-II protein levels in pulmonary vascular smooth muscle and endothelial cells are observed in patients with IPAH and animals with experimental PH. Long and colleagues propose a mechanism in which BMPR-II is internalized from the plasma membrane and ubiquitinated. The ubiquitinated BMPR-II protein is then engulfed by the autophagosome and degraded through a lysosomal-mediated pathway. BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; LC3B, microtubule-associated protein light chain 3.
See this image and copyright information in PMC

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