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Case Reports
. 2013 Jan-Mar;20(1):83-6.
doi: 10.4103/0974-9233.106400.

Transient increased exudation after photodynamic therapy of intraocular tumors

Arman Mashayekhi  1 , Carol L Shields, Jerry A Shields
Affiliations
Case Reports

Transient increased exudation after photodynamic therapy of intraocular tumors

Arman Mashayekhi et al. Middle East Afr J Ophthalmol. 2013 Jan-Mar.

Abstract

To report transient increased exudation after photodynamic therapy (PDT) of three different intraocular tumors (retinal hemangioblastoma, retinal astrocytoma, amelanotic choroidal melanoma). PDT with verteporfin (6 mg/m(2) body surface area) was delivered at a dose of 50 J/cm(2) and intensity of 600 mW/cm(2) over 83 s. All patients experienced decreased vision within a few days following PDT. Optical coherence tomography showed development of subfoveal fluid in all cases and noncystoid intraretinal edema in the eye with juxtapapillary retinal hemangioblastoma. There was complete absorption of retinal/subretinal fluid with improvement of visual acuity to 20/20 in all cases between 3 weeks to 4 months after PDT.

Keywords: Astrocytoma; Choroidal Melanoma; Complication; Exudation; Eye; Photodynamic Therapy; Retinal Hemangioblastoma; Serous Retinal Detachment; Tumor.

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Conflict of interest statement

Conflict of Interest: No.

Figures

Figure 1
Figure 1
(a) Juxtapapillary retinal hemangioblastoma with adjacent lipid exudation. Note minimal lipid exudation in the papillomacular bundle region (b) Foveal contour is normal before photodynamic theraphy (PDT) (c) OCT performed 1 day after PDT shows retinal edema and subretinal fluid under the foveola (d) Three weeks after PDT there is complete reabsorption of intraretinal and subretinal fluid. There are a few focal intraretinal optically dense juxtafoveal deposits consistent with ophthalmoscopically visible lipid exudates
Figure 2
Figure 2
(a) Partially pigmented retinal astrocytoma (needle biopsy proven) with lipid exudation at the superior, inferior, and nasal margins extending into the fovea, forming a foveal star (b) OCT before PDT reveals moderate intraretinal cystoid edema at the fovea (c) Three days after PDT there is increased subretinal fluid (d) Four months later, there is complete reabsorption of intraretinal and subretinal fluid leaving retinal atrophy
Figure 3
Figure 3
(a) Color fundus photograph showing small amelanotic choroidal melanoma with documented growth (b) OCT shows normal fovea before PDT (c) Eleven days after PDT, neurosensory retinal detachment extending under the fovea is evident (d) Three months after PDT, subretinal fluid has completely disappeared and foveal contour has returned to normal
See this image and copyright information in PMC

References

    1. Oleinick NL, Evans HH. The photobiology of photodynamic therapy: Cellular targets and mechanisms. Radiat Res. 1998;150:S146–56. - PubMed
    1. Henderson BW, Fingar VH. Oxygen limitation of direct tumor cell kill during photodynamic treatment of a murine tumor model. Photochem Photobiol. 1989;49:299–304. - PubMed
    1. Fingar VH, Wieman TJ, Wiehle SA, Cerrito PB. The role of microvascular damage in photodynamic therapy: The effect of treatment on vessel constriction, permeability, and leukocyte adhesion. Cancer Res. 1992;52:4914–21. - PubMed
    1. Fingar VH. Vascular effects of photodynamic therapy. J Clin Laser Med Surg. 1996;14:323–8. - PubMed
    1. Schmidt-Erfurth UM, Michels S, Kusserow C, Jurklies B, Augustin AJ. Photodynamic therapy for symptomatic choroidal hemangioma: Visual and anatomic results. Ophthalmology. 2002;109:2284–94. - PubMed

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