Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jun;118(6):1176-80.
doi: 10.3171/2013.3.JNS122282. Epub 2013 Apr 12.

Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review

Tiffany R Hodges  1 , Bryan D Choi, Darell D Bigner, Hai Yan, John H Sampson
Affiliations
Review

Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review

Tiffany R Hodges et al. J Neurosurg. 2013 Jun.

Abstract

Isocitrate dehydrogenase 1 (IDH1) mutations have been discovered to be frequent and highly conserved in secondary glioblastoma multiforme and lower-grade gliomas. Although IDH1 mutations confer a unique genotype that has been associated with a favorable prognosis, the role of the mutated IDH1 enzyme and its metabolites in tumor initiation and maintenance remains unresolved. However, given that IDH1 mutations are homogeneously expressed and are limited solely to tumor tissue, targeting this mutation could potentially yield novel treatment strategies for patients with glioblastoma multiforme.

PubMed Disclaimer

Conflict of interest statement

Disclosure

The authors do not disclose any potential conflicts of interest.

Figures

Figure 1
Figure 1
Diagram of the molecular consequences of the IDH1 mutation.
See this image and copyright information in PMC

References

    1. Alderton GK. Genetics: IDH mosaicism in enchondromatosis syndromes. Nat Rev Cancer. 2012;12:6. - PubMed
    1. Amary MF, Bacsi K, Maggiani F, Damato S, Halai D, Berisha F, et al. IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. J Pathol. 2011;224:334–343. - PubMed
    1. Andronesi OC, Kim GS, Gerstner E, Batchelor T, Tzika AA, Fantin VR, et al. Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. Sci Transl Med. 2012;4:116ra114. - PMC - PubMed
    1. Balss J, Meyer J, Mueller W, Korshunov A, Hartmann C, von Deimling A. Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol. 2008;116:597–602. - PubMed
    1. Bleeker FE, Lamba S, Leenstra S, Troost D, Hulsebos T, Vandertop WP, et al. IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors. Hum Mutat. 2009;30:7–11. - PubMed

Publication types

Substances