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Review
. 2013 Oct;24(5):909-15.
doi: 10.1016/j.copbio.2013.03.021. Epub 2013 Apr 10.

Tissue engineering and regenerative medicine as applied to the gastrointestinal tract

Khalil N Bitar  1 , Elie Zakhem
Affiliations
Review

Tissue engineering and regenerative medicine as applied to the gastrointestinal tract

Khalil N Bitar et al. Curr Opin Biotechnol. 2013 Oct.

Abstract

The gastrointestinal (GI) tract is a complex system characterized by multiple cell types with a determined architectural arrangement. Tissue engineering of the GI tract aims to reinstate the architecture and function of all structural layers. The key point for successful tissue regeneration includes the use of cells/biomaterials that elucidate minimal immune response after implantation. Different biomaterial choices and cell sources have been proposed to engineer the GI tract. This review summarizes the recent advances in bioengineering the GI tract with emphasis on cell sources and scaffolding biomaterials.

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