Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 May;43(5):544-9.
doi: 10.7164/antibiotics.43.544.

Chemical modification of erythromycins. IV. Synthesis and biological properties of 6-O-methylerythromycin B

S Morimoto  1 , T Adachi, Y Misawa, T Nagate, Y Watanabe, S Omura
Affiliations
Free article

Chemical modification of erythromycins. IV. Synthesis and biological properties of 6-O-methylerythromycin B

S Morimoto et al. J Antibiot (Tokyo). 1990 May.
Free article

Abstract

6-O-Methylerythromycin B has been synthesized from erythromycin B via regioselective methylation of the 6-hydroxyl group in 71% overall yield. This compound shows in vitro antibacterial activity comparable to erythromycins A and B and exhibits superior in vivo activity with improved pharmacokinetic properties.

PubMed Disclaimer