Metabolism: Glutamine connections

Comment

Darren J Burgess. Nat Rev Cancer. 2013 May.

. 2013 May;13(5):293.

doi: 10.1038/nrc3515. Epub 2013 Apr 12.

No abstract available

Comment on

In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.
Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O. Gameiro PA, et al. Cell Metab. 2013 Mar 5;17(3):372-85. doi: 10.1016/j.cmet.2013.02.002. Cell Metab. 2013. PMID: 23473032 Free PMC article.
The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation.
Reid MA, Wang WI, Rosales KR, Welliver MX, Pan M, Kong M. Reid MA, et al. Mol Cell. 2013 Apr 25;50(2):200-11. doi: 10.1016/j.molcel.2013.02.008. Epub 2013 Mar 14. Mol Cell. 2013. PMID: 23499005
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC. Son J, et al. Nature. 2013 Apr 4;496(7443):101-5. doi: 10.1038/nature12040. Epub 2013 Mar 27. Nature. 2013. PMID: 23535601 Free PMC article.