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Meta-Analysis
. 2013 Apr 9;8(4):e61153.
doi: 10.1371/journal.pone.0061153. Print 2013.

Adiponectin-11377CG gene polymorphism and type 2 diabetes mellitus in the Chinese population: a meta-analysis of 6425 subjects

Yan-Yan Li  1 , Zhi-Jian Yang, Chuan-Wei Zhou, Xiang-Ming Wang, Yun Qian, Jian Xu, Bei Wang, Jun Wu
Affiliations
Meta-Analysis

Adiponectin-11377CG gene polymorphism and type 2 diabetes mellitus in the Chinese population: a meta-analysis of 6425 subjects

Yan-Yan Li et al. PLoS One. .

Abstract

Background: Although adiponectin -11377CG gene polymorphism is implied to be associated with increased type 2 diabetes mellitus (T2DM) risk, results of individual studies are inconsistent.

Objective and methods: A meta-analysis consisting of 12 individual studies, including a total of 6425 participants, was carried out in order to investigate the association of adiponectin -11377CG gene polymorphism with T2DM. The pooled odds ratio (OR) and its corresponding confidence interval (CI) at 95% were assessed through the random- or fixed- effect model.

Results: A significant relationship was observed between adiponectin -11377CG gene polymorphism and T2DM under allelic (OR: 1.150, 95% CI: 1.060 to 1.250, P = 0.001), recessive (OR: 1.450, 95% CI: 1.180-1.770, P = 0.0004), dominant (OR: 1.071, 95% CI: 1.013-1.131, P = 0.015), additive (OR: 1.280, 95% CI: 1.090-1.510, P = 0.002), and homozygous genetic models (OR: 1.620, 95% CI: 1.310-1.990, P<0.00001). No significant association was found between them under the heterozygous genetic model (OR: 1.640, 95% CI: 0.850-3.170, P = 0.140).

Conclusions: Adiponectin -11377CG gene polymorphism was significantly associated with T2DM risk susceptibility. G allele carriers are predisposed to T2DM risk.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Forest plot of T2DM associated with adiponectin −11377 CG gene polymorphism under an allelic genetic model (distribution of G allelic frequency of adiponectin −11377 gene).
Figure 2
Figure 2. Forest plot of T2DM associated with adiponectin −11377 CG gene polymorphism under a recessive genetic model (GG vs. CG+CC).
Figure 3
Figure 3. Forest plot of T2DM associated with adiponectin −11377 CG gene polymorphism under an additive genetic model (G vs. C).
Figure 4
Figure 4. Forest plot of T2DM associated with adiponectin −11377 CG gene polymorphism under a homozygous genetic model (GG vs. CC).
Figure 5
Figure 5. Forest plot of T2DM associated with adiponectin −11377 CG gene polymorphism under a heterozygous genetic model (CG vs. CC).
Figure 6
Figure 6. Forest plot of T2DM associated with adiponectin −11377 CG gene polymorphism under an additive genetic model stratified by T1 (G vs. C).
Figure 7
Figure 7. Forest plot of T2DM associated with adiponectin −11377 CG gene polymorphism under a heterozygous genetic model stratified by T1 (CG vs. CC).
Figure 8
Figure 8. Funnel plot for studies of the association of T2DM associated with adiponectin −11377 CG gene polymorphism under an allelic genetic model (distribution of G allelic frequency of adiponectin −11377 gene).
The horizontal and vertical axis correspond to the OR and confidence limits. OR: odds ratio; SE: standard error.
See this image and copyright information in PMC

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