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Review
. 2013:2013:963248.
doi: 10.1155/2013/963248. Epub 2013 Mar 24.

Review on natural coumarin lead compounds for their pharmacological activity

K N Venugopala  1 , V Rashmi, B Odhav
Affiliations
Review

Review on natural coumarin lead compounds for their pharmacological activity

K N Venugopala et al. Biomed Res Int. 2013.

Abstract

Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective properties. Dietary exposure to benzopyrones is significant as these compounds are found in vegetables, fruits, seeds, nuts, coffee, tea, and wine. In view of the established low toxicity, relative cheapness, presence in the diet, and occurrence in various herbal remedies of coumarins, it appears prudent to evaluate their properties and applications further.

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Figures

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Figure 1
Coumarin analogue warfarin and vitamin K cycle.
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See this image and copyright information in PMC

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