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. 2013 Apr 26;76(4):702-9.
doi: 10.1021/np400041y. Epub 2013 Apr 15.

Xanthoquinodins from the endolichenic fungal strain Chaetomium elatum

Guo-Dong Chen  1 , Ying Chen, Hao Gao, Li-Qing Shen, Yang Wu, Xiao-Xia Li, Yan Li, Liang-Dong Guo, Ying-Zhou Cen, Xin-Sheng Yao
Affiliations

Xanthoquinodins from the endolichenic fungal strain Chaetomium elatum

Guo-Dong Chen et al. J Nat Prod. .

Abstract

Five new xanthoquinodins, A4-A6 (1-3), B4 (4), and B5 (5), were isolated from the crude extract of the endolichenic fungal strain Chaetomium elatum (No. 63-10-3-1), along with three known xanthoquinodins, A1-A3 (6-8). Their structures were determined by detailed spectroscopic analysis and comparison of the NMR data with those of the closely related compounds previously reported. The absolute configuration of 1 was established by X-ray crystallographic analysis and ECD calculation. The cytotoxic activity of all compounds was tested against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines.

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