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. 1975 Feb;7(2):293-6.

Ocular penetration of pilocarpine: the effect of pH on the ocular penetration of pilocarpine

R M Ramer, A R Gasset
  • PMID: 235874

Ocular penetration of pilocarpine: the effect of pH on the ocular penetration of pilocarpine

R M Ramer et al. Ann Ophthalmol. 1975 Feb.

Abstract

Under the conditions of this study, tritiated pilocarpine was topically applied to rabbits, and the activity in the aqueous humor was measured at selected times. It was found that higher pH affords greater pilocarpine penetration. At pH 7.5, for example, penetration into the aqueous was twice as great as at pH 4.

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