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. 2013 Aug;94(2):207-10.
doi: 10.1038/clpt.2013.59. Epub 2013 Mar 19.

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation

A R Shuldiner  1 , M V Relling, J F Peterson, J K Hicks, R R Freimuth, W Sadee, N L Pereira, D M Roden, J A Johnson, T E Klein; Pharmacogenomics Research Network Translational Pharmacogenetics Program Group; Alan R Shuldiner, Mark Vesely, Shawn W Robinson, Nicholas Ambulos Jr, Sanford A Stass, Mark D Kelemen, Lawrence A Brown, Toni I Pollin, Amber L Beitelshees, Richard Y Zhao, Ruth E Pakyz, Kathleen Palmer, Tameka Alestock, Courtney O'Neill, Kristin Maloney, Amie Branham, Danielle Sewell, Mary V Relling, Kristine Crews, James Hoffman, Shane Cross, Cyrine Haidar, Don Baker, J Kevin Hicks, Gillian Bell, Fran Greeson, Aditya Gaur, Ulrike Reiss, Alicia Huettel, Cheng Cheng, Amar Gajjar, Alberto Pappo, Scott Howard, Melissa Hudson, Ching-Hon Pui, Sima Jeha, William E Evans, Ulrich Broeckel, Russ B Altman, Li Gong, Michelle Whirl-Carrillo, Teri E Klein, Wolfgang Sadee, Kandamurugu Manickam, Kevin M Sweet, Peter J Embi, Dan Roden, Josh Peterson, Josh Denny, Jonathan Schildcrout, Erica Bowton, Jill Pulley, Marc Beller, Jennifer Mitchell, Ioana Danciu, Lisa Price, Naveen L Pereira, Richard Weinshilboum, Liewei Wang, Julie A Johnson, David Nelson, Michael Clare-Salzler, Amanda Elsey, Benjamin Burkley, Taimour Langaee, Felix Liu, David Nessl, Hui-Jia Dong, Larry Lesko, Robert R Freimuth, Christopher G Chute
Affiliations

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation

A R Shuldiner et al. Clin Pharmacol Ther. 2013 Aug.

Abstract

The pace of discovery of potentially actionable pharmacogenetic variants has increased dramatically in recent years. However, the implementation of this new knowledge for individualized patient care has been slow. The Pharmacogenomics Research Network (PGRN) Translational Pharmacogenetics Program seeks to identify barriers and develop real-world solutions to implementation of evidence-based pharmacogenetic tests in diverse health-care settings. Dissemination of the resulting toolbox of “implementation best practices” will prove useful to a broad audience.

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Conflict of interest statement

CONFLICT OF INTEREST

M.V.R. received patent royalties from TPMT genotyping tests. The other authors declared no conflict of interest.

Figures

Figure 1
Figure 1
Organizational structure and goals of the Pharmacogenomics Research Network Translational Pharmacogenomics Program. CAP, College of American Pathologists; CLIA, Clinical Laboratory Improvement Amendments; CPIC, Clinical Pharmacogenetics Implementation Consortium; PharmGKB, The Pharmacogenomics Knowledgebase; PHONT, Pharmacogenomic Ontology; TPP, Translational Pharmacogenetics Program.
See this image and copyright information in PMC

References

    1. Relling MV, Klein TE. CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network. Clin. Pharmacol. Ther. 2011;89:464–467. - PMC - PubMed
    1. Crews KR, Hicks JK, Pui CH, Relling MV, Evans WE. Pharmacogenomics and individualized medicine: translating science into practice. Clin. Pharmacol. Ther. 2012;92:467–475. - PMC - PubMed
    1. Johnson JA, Burkley BM, Langaee TY, Clare-Salzler MJ, Klein TE, Altman RB. Implementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping array. Clin. Pharmacol. Ther. 2012;92:437–439. - PMC - PubMed
    1. Lieb W, Völzke H, Pulley JM, Roden DM, Kroemer HK. Strategies for personalized medicine-based research and implementation in the clinical workflow. Clin. Pharmacol. Ther. 2012;92:443–445. - PubMed

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