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. 2013 Aug;94(2):214-7.
doi: 10.1038/clpt.2013.72. Epub 2013 Apr 3.

The CLIPMERGE PGx Program: clinical implementation of personalized medicine through electronic health records and genomics-pharmacogenomics

O Gottesman  1 , S A Scott, S B Ellis, C L Overby, A Ludtke, J-S Hulot, J Hall, K Chatani, K Myers, J L Kannry, E P Bottinger
Affiliations

The CLIPMERGE PGx Program: clinical implementation of personalized medicine through electronic health records and genomics-pharmacogenomics

O Gottesman et al. Clin Pharmacol Ther. 2013 Aug.
No abstract available

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Conflict of interest statement

Conflict of Interest

The other authors declared no conflicts of interest.

Figures

Figure 1
Figure 1
A platform for implementation of genome-informed clinical decision support (CDS). Saliva samples from BioMe patients sent to the Mount Sinai Genetic Testing Laboratory are subjected to clinical pharmacogenomic testing. Valid genotypes are released to the CLIPMERGE database, which also contains longitudinal clinical data extracted from the Electronic Health Record (EHR). These data are assessed by the Clinical Risk Assessment Engine (CRAE), which contains pre-specified rules relating actionable genotype-drug pairs to genome-informed advice messages. If a rule is fulfilled, decision support is delivered in real time via the EHR. A mockup of CDS for a clopidogrel (Plavix®) poor metabolizer is shown, consisting of a text segment, a reference link and an order set with suggested alternative medications.
See this image and copyright information in PMC

References

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