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. 2013 Mar;16(1):12-5.
doi: 10.4048/jbc.2013.16.1.12. Epub 2013 Mar 31.

Eribulin for advanced breast cancer: a drug evaluation

Alaaeldin Shablak  1
Affiliations

Eribulin for advanced breast cancer: a drug evaluation

Alaaeldin Shablak. J Breast Cancer. 2013 Mar.

Abstract

Eribulin is a synthetic microtubule dynamics inhibitor that was developed from a marine natural product halichondrin B. It exhibited in vitro and in vivo activities against a wide number of malignancies. A number of advanced phase trials showed improved survival following eribulin treatment in pretreated advanced breast cancer patients. This review provides an overview of the background to the therapeutic use of eribulin in oncology, including its pharmacology, pharmacokinetics, clinical efficacy, safety, and potential economic factors.

Keywords: Breast neoplasms; Eribulin; Microtubule inhibitor.

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Conflict of interest statement

The authors declare that they have no competing interests.

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