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. 2013 Nov;7(6):999-1003.
doi: 10.1111/irv.12062.

Influenza C virus–associated community-acquired pneumonia in children

Nicola Principi, Alessia Scala, Cristina Daleno, Susanna Esposito

Influenza C virus–associated community-acquired pneumonia in children

Nicola Principi et al. Influenza Other Respir Viruses. 2013 Nov.

Abstract

To evaluate the impact of influenza C (ICV) infection in children with community-acquired pneumonia (CAP), all of the children consecutively seen during 4 influenza seasons with respiratory symptoms and radiographically confirmed CAP were prospectively evaluated. ICV was identified in the respiratory secretions of five of 391 patients (1·3%). In children with ICV-associated CAP, clinical data were similar to those observed in children with IAV-associated CAP and worse than those observed in children with IBV-associated. The phylogenetic tree showed that the sequenced strains clustered in two of the six ICV lineages. These findings highlight that ICV can be a cause of CAP of children and that this can be severe enough to require hospitalization.

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Figures

Figure 1
Figure 1
Phylogenetic tree of influenza C viruses based on a region of about 1000 bp of the HE gene. The viruses isolated in this study (Milan, Italy) are marked by a black symbol. The other sequences have been described elsewhere.7, 9, 10, 11 The values at the nodes are bootstrap supported on the basis of 500 replicates.
See this image and copyright information in PMC

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