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Comment
. 2013 Apr 17;14(4):111.
doi: 10.1186/gb-2013-14-4-111.

The fractured genome of HeLa cells

David Mittelman, John H Wilson
Comment

The fractured genome of HeLa cells

David Mittelman et al. Genome Biol. .

Abstract

Whole-genome sequencing of the widely used HeLa cell line provides a nucleotide-resolution view of a greatly mutated and in some places shattered genome.

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Figures

Figure 1
Figure 1
Circos plot illustrating the genomic features of the HeLa genome. From outside to inside, the tracks represent: read depth (100 kb binned coverage); copy number (color gradient from light green for one copy to dark red for more than six copies); zygosity (pink, heterozygous; purple, homozygous); SNV density (1 Mb binned SNV count; darker blue for greater density); and translocation calls (colored arcs; light blue, from paired-end sequencing data; light green, from mate pair data; orange, from both datasets). Reproduced, with permission, from [2].
See this image and copyright information in PMC

Comment on

  • The genomic and transcriptomic landscape of a HeLa cell line.
    Landry JJ, Pyl PT, Rausch T, Zichner T, Tekkedil MM, Stütz AM, Jauch A, Aiyar RS, Pau G, Delhomme N, Gagneur J, Korbel JO, Huber W, Steinmetz LM. Landry JJ, et al. G3 (Bethesda). 2013 Aug 7;3(8):1213-24. doi: 10.1534/g3.113.005777. G3 (Bethesda). 2013. PMID: 23550136 Free PMC article.

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