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. 2013 Apr 17;8(1):14.
doi: 10.1186/1750-9378-8-14.

The role of human papillomavirus in head and neck cancer in Senegal

Cathy Ndiaye  1 , Laia Alemany, Yankhoba Diop, Nafissatou Ndiaye, Marie-Joseph Diémé, Sara Tous, Jo Ellen Klaustermeier, Maria Alejo, Xavier Castellsagué, F Xavier Bosch, Helen Trottier, Silvia de Sanjosé
Affiliations

The role of human papillomavirus in head and neck cancer in Senegal

Cathy Ndiaye et al. Infect Agent Cancer. .

Abstract

Background: Exploring the presence and role of human papillomavirus (HPV) in head and neck cancer (HNC) is a necessary step to evaluate the potential impact of HPV prophylactic vaccines.

Objective: To assess the prevalence and oncogenic role of HPV in HNC in Senegal.

Methods: This is a multicenter cross-sectional study. Paraffin-embedded blocks of cases diagnosed with invasive HNC between 2002 and 2010 were collected from 4 pathology laboratories in Senegal. Presence of HPV DNA was determined by PCR and DEIA, and genotyping performed with LiPA25. Tubulin analysis was performed to assess DNA quality. HPV DNA-positive cases were tested for p16INK4a expression.

Findings: A total of 117 cases were included in the analysis: 71% were men, mean age was 52 years old (SD ±18.3), and 96% of cases were squamous cell carcinoma. Analysis was performed on 41 oral cavity tumors, 64 laryngeal tumors, 5 oropharyngeal tumors and 7 pharyngeal tumors. Only four cases (3.4%; 95% CI = 0.9%-8.5%) harbored HPV DNA. HPV types detected were HPV16, HPV35 and HPV45. However, among HPV-positive cases, none showed p16INK4a overexpression.

Conclusion: Our findings indicate that HPV DNA prevalence in HNC in Senegal is very low, suggesting that HPV is not a strong risk factor for these cancers. Additional larger studies are needed to confirm these findings and explore other potential risk factors specific to the region.

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Figures

Figure 1
Figure 1
Algorithm of head and neck cancer cases included in the study.
See this image and copyright information in PMC

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