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. 2013 Apr 11;18(15):20453.

Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013

T Kageyama  1 , S Fujisaki, E Takashita, H Xu, S Yamada, Y Uchida, G Neumann, T Saito, Y Kawaoka, M Tashiro
Affiliations

Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013

T Kageyama et al. Euro Surveill. .

Erratum in

  • Euro Surveill. 2013;18(16):20459

Abstract

Novel influenza viruses of the H7N9 subtype have infected 33 and killed nine people in China as of 10 April 2013. Their haemagglutinin (HA) and neuraminidase genes probably originated from Eurasian avian influenza viruses; the remaining genes are closely related to avian H9N2 influenza viruses. Several characteristic amino acid changes in HA and the PB2 RNA polymerase subunit probably facilitate binding to human-type receptors and efficient replication in mammals, respectively, highlighting the pandemic potential of the novel viruses.

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Conflict of interest statement

Conflict of interest

None declared.

Figures

Figure 1.
Figure 1.
Phylogenetic analysis of the haemagglutinin (A) and neuraminidase (B) genes of the novel influenza A(H7N9) viruses, China, February - April 2013 (n=7)
Figure 1.
Figure 1.
Phylogenetic analysis of the haemagglutinin (A) and neuraminidase (B) genes of the novel influenza A(H7N9) viruses, China, February - April 2013 (n=7)
Figure 2.
Figure 2.
Phylogenetic analysis of the six remaining genes of the novel influenza A(H7N9) viruses, China, February – April, 2013 (n=7)
Figure 2.
Figure 2.
Phylogenetic analysis of the six remaining genes of the novel influenza A(H7N9) viruses, China, February – April, 2013 (n=7)
Figure 2.
Figure 2.
Phylogenetic analysis of the six remaining genes of the novel influenza A(H7N9) viruses, China, February – April, 2013 (n=7)
Figure 2.
Figure 2.
Phylogenetic analysis of the six remaining genes of the novel influenza A(H7N9) viruses, China, February – April, 2013 (n=7)
Figure 2.
Figure 2.
Phylogenetic analysis of the six remaining genes of the novel influenza A(H7N9) viruses, China, February – April, 2013 (n=7)
Figure 2.
Figure 2.
Phylogenetic analysis of the six remaining genes of the novel influenza A(H7N9) viruses, China, February – April, 2013 (n=7)
Figure 3.
Figure 3.
Schematic diagram of novel influenza A(H7N9) virus generation
Figure 4.
Figure 4.
Amino acid changes in the novel influenza A(H7N9) viruses that may affect their receptor-binding properties, China, February - April 2013 (n=7)
See this image and copyright information in PMC

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