The treatment of angiocentric glioma: case report and literature review

Abstract

Angiocentric glioma is a recently described tumor recognized since 2007 by the World Health Organization Classification of Tumours of the Central Nervous System. We present the only case of angiocentric glioma at our institution in the last 15 years and review the literature in an attempt to establish prognostic parameters. Our search revealed only 27 cases of angiocentric glioma in the literature. The most common presenting symptom of angiocentric glioma was seizures. Gross total resection of the lesion was curative, without need for radiation or chemotherapy.

Figure 1

Magnetic resonance imaging of the brain. a) axial fluid-attenuated inversion recovery (FLAIR) MR image showing tumor signal; b) axial T2-weighted MR image obtained at the same level, demonstrating the hyperintense tumor signal; c) postoperative T1-weighted MR image with contrast; and d) postoperative T2 MR image showing complete resection of the tumor.

Figure 2

Pathology evaluation of tumor. a) Hematoxylin and eosin stain showing tumor cells; b) interface between the brain and the tumor; c) tumor cells that form pseudorosette type structures around the blood vessels; and d) tumor cells in subpial locations arranged in radial arrays perpendicular to the pial surface.