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. 2013 Apr 11:7:24.
doi: 10.3389/fnint.2013.00024. eCollection 2013.

Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques

Fei Du  1 , Dost Ongür
Affiliations

Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques

Fei Du et al. Front Integr Neurosci. .

Abstract

In this manuscript we present novel MRI approaches to dissecting axon vs. myelin abnormalities in psychiatric disorders. Existing DTI approaches are not able to provide specific information on these subcellular elements but novel approaches are beginning to do so. We review two approaches (magnetization transfer ratio-MTR; and diffusion tensor spectroscopy-DTS) and the theoretical framework for interpreting data derived from these approaches. Work is ongoing to collect data that will answer some relevant questions using these techniques in schizophrenia and related conditions.

Keywords: DTS; MTR; axon; g-ratio; myelin.

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Figures

Figure 1
Figure 1
Schematic of proposed white matter measures.
Figure 2
Figure 2
Sample spectra acquired during the diffusion experiment.
Figure 3
Figure 3
Proposed abnormalities in schizophrenia.
Figure 4
Figure 4
Magnetization transfer ratio data.
See this image and copyright information in PMC

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