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. 2013 Jun;103(6):e14-23.
doi: 10.2105/AJPH.2013.301273. Epub 2013 Apr 18.

Clinical uncertainties, health service challenges, and ethical complexities of HIV "test-and-treat": a systematic review

Sonali P Kulkarni  1 , Kavita R Shah, Karthik V Sarma, Anish P Mahajan
Affiliations

Clinical uncertainties, health service challenges, and ethical complexities of HIV "test-and-treat": a systematic review

Sonali P Kulkarni et al. Am J Public Health. 2013 Jun.

Abstract

Despite the HIV "test-and-treat" strategy's promise, questions about its clinical rationale, operational feasibility, and ethical appropriateness have led to vigorous debate in the global HIV community. We performed a systematic review of the literature published between January 2009 and May 2012 using PubMed, SCOPUS, Global Health, Web of Science, BIOSIS, Cochrane CENTRAL, EBSCO Africa-Wide Information, and EBSCO CINAHL Plus databases to summarize clinical uncertainties, health service challenges, and ethical complexities that may affect the test-and-treat strategy's success. A thoughtful approach to research and implementation to address clinical and health service questions and meaningful community engagement regarding ethical complexities may bring us closer to safe, feasible, and effective test-and-treat implementation.

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Figures

FIGURE 1—
FIGURE 1—
Summary of systematic review article selection process.
See this image and copyright information in PMC

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