Treatment planning in molecular radiotherapy

Abstract

In molecular radiotherapy a radionuclide or a radioactively labelled pharmaceutical is administered to the patient. Treatment planning therefore comprises the determination of activity to administer. This administered activity should maximize tumour cell sterilization while minimizing normal tissue damage. In this work we present different approaches that are frequently used for determining the suitable activity. These approaches may be cohort- based as in chemotherapy, or patient-specific using dosimetry based on individual biokinetics. The approaches are different with respect to the input complexity, the corresponding costs and - in consequence - the quality of the therapy. In addition, a general scheme for data collection and analysis is proposed. To develop an effective and safe treatment, elaborate data need to be obtained. The main challenges, however, are collecting these complex data and analyse them properly.

Keywords: Dosimetrie; Molekulare Radiotherapie; Nuklearmedizin; Radionuklidtherapie; Therapieplannung; Therapy planning; dosimetry; molecular radiotherapy; nuclear medicine; targeted radionuclide therapy.