Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Dec;55(4):555-7.
doi: 10.1111/j.1476-5381.1975.tb07432.x.

The actions of flupenthixol upon 5-hydroxytryptamine-induced aggregation and the uptake of 5-hydroxytryptamine and dopamine by human blood platelets

D J Boullin, R P Grimes, M W Orr

The actions of flupenthixol upon 5-hydroxytryptamine-induced aggregation and the uptake of 5-hydroxytryptamine and dopamine by human blood platelets

D J Boullin et al. Br J Pharmacol. 1975 Dec.

Abstract

The effects of the alpha- and beta-isomers of flupenthixol on 5-hydroxytryptamine (5-HT)-induced platelet aggregation and on 5-HT and dopamine uptake were investigated. Alpha-Flupenthixol was 185 times more potent than the beta-isomer as an inhibitor of platelet aggregation. In contrast both isomers were equipotent as inhibitors of uptake of 5-HT and dopamine. The data suggest that 5-HT-induced aggregation and uptake are separate processes.

PubMed Disclaimer

References

    1. Br J Pharmacol. 1975 Jan;53(1):121-5 - PubMed
    1. Acta Pharmacol Toxicol (Copenh). 1973;33(5):353-62 - PubMed
    1. Br J Pharmacol. 1972 Jan;44(1):117-39 - PubMed
    1. J Physiol. 1972 Mar;221(2):415-26 - PubMed
    1. Br J Psychiatry. 1969 Dec;115(529):1399-402 - PubMed

LinkOut - more resources