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Review
. 2013 May;52(5 Suppl):S15-20.
doi: 10.1016/j.jadohealth.2012.09.019.

Identifying opportunities for cancer prevention during preadolescence and adolescence: puberty as a window of susceptibility

Frank M Biro  1 , Julianna Deardorff
Affiliations
Review

Identifying opportunities for cancer prevention during preadolescence and adolescence: puberty as a window of susceptibility

Frank M Biro et al. J Adolesc Health. 2013 May.

Erratum in

  • J Adolesc Health. 2013 Jun;52(6);808

Abstract

Purpose: Early life exposures during times of rapid growth and development are recognized increasingly to impact later life. Epidemiologic studies document an association between exposures at critical windows of susceptibility with outcomes as diverse as childhood and adult obesity, timing of menarche, and risk for hypertension or breast cancer.

Methods: This article briefly reviews the concept of windows of susceptibility for providers who care for adolescent patients.

Results: The theoretical bases for windows of susceptibility is examined, evaluating the relationship between pubertal change and breast cancer as a paradigm, and reviewing the underlying mechanisms, such as epigenetic modification.

Conclusions: The long-term sequela of responses to early exposures may impact other adult morbidities; addressing these exposures represents an important challenge for contemporary medicine.

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Figures

FIGURE 1
FIGURE 1
Pubertal milestones and breast development
See this image and copyright information in PMC

References

    1. Godfrey KM, Gluckman PD, Hanson MA. Developmental origins of metabolic disease: Life course and intergenerational perspectives. Trends Endocrinol Metab. 2010;21:199–205. http://dx.doi.org/10.1016/j.tem.2009.12.008. - DOI - PubMed
    1. Okasha M, McCarron P, Gunnell D, et al. Exposures in childhood, adolescence and early adulthood and breast cancer risk: a systematic review of the literature. Breast Cancer Res Treat. 2003;78:223–76. doi: 10.1023/A:1022988918755. - DOI - PubMed
    1. Andersen LG, Ängquist L, Eriksson JG, et al. Birth weight, childhood body mass index and risk of coronary heart disease in adults: Combined historical cohort studies. PLoS One. 2010;5:e14126. http://dx.doi.org/10.1016/j.tem.2009.12.008. - DOI - PMC - PubMed
    1. Barker DJP, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet. 1986;327:1077–81. http://dx.doi.org/10.1016/S0140-6736(86)91340-1. - DOI - PubMed
    1. Leon DA, Lithell HO, Vågerö D, et al. Reduced fetal growth rate and increased risk of death from ischaemic heart disease: Cohort study of 15,000 Swedish men and women born 1915–29. BMJ. 1998;317:241–5. http://dx.doi.org/10.1136/bmj.317.7153.241. - DOI - PMC - PubMed

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