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Comment
. 2013 Apr 18;38(4):628-30.
doi: 10.1016/j.immuni.2013.03.006.

Dysfunctional HDL takes its toll in chronic kidney disease

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Comment

Dysfunctional HDL takes its toll in chronic kidney disease

Kathryn J Moore et al. Immunity. .
Free article

Abstract

Why patients with chronic kidney disease have elevated cardiovascular risk remains elusive. In this issue of Immunity, Speer et al. (2013) show that natural modification of high density lipoprotein promotes hypertension through a Toll-like receptor-dependent mechanism.

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  • Abnormal high-density lipoprotein induces endothelial dysfunction via activation of Toll-like receptor-2.
    Speer T, Rohrer L, Blyszczuk P, Shroff R, Kuschnerus K, Kränkel N, Kania G, Zewinger S, Akhmedov A, Shi Y, Martin T, Perisa D, Winnik S, Müller MF, Sester U, Wernicke G, Jung A, Gutteck U, Eriksson U, Geisel J, Deanfield J, von Eckardstein A, Lüscher TF, Fliser D, Bahlmann FH, Landmesser U. Speer T, et al. Immunity. 2013 Apr 18;38(4):754-68. doi: 10.1016/j.immuni.2013.02.009. Epub 2013 Mar 7. Immunity. 2013. PMID: 23477738

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