Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines
- PMID: 23601689
- PMCID: PMC3681204
- DOI: 10.1016/j.immuni.2012.12.008
Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines
Abstract
Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.
Copyright © 2013 Elsevier Inc. All rights reserved.
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Comment in
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From finger pricks to point-and-click.Immunity. 2013 Apr 18;38(4):622-4. doi: 10.1016/j.immuni.2013.04.003. Immunity. 2013. PMID: 23601677 Free PMC article.
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References
-
- Alakulppi N, Seikku P, Jaatinen T, Holmberg C, Laine J. Feasibility of diagnosing subclinical renal allograft rejection in children by whole blood gene expression analysis. Transplantation. 2008;86:1222–1228. - PubMed
-
- Benjamini Y, Hochberg Y. Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J.R. Stat. Soc. 1995;57:289–300.
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