Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Oct;21(4):137-51.
doi: 10.1007/s11357-998-0024-6.

Effect of age on cytokine production in humans

E D Bernstein, D M Murasko

Effect of age on cytokine production in humans

E D Bernstein et al. Age (Omaha). 1998 Oct.

Abstract

Aging is accompanied by many changes in immune response, with the most consistent and dramatic alterations occurring within the T cell compartment. Since cytokines are central to immune cell communications, age-associated changes in cytokine production may contribute to these alterations. While data from murine studies suggest a switch from a Th1 (IL-2, IFNγ) to a Th2 (IL-4, IL-6, IL-10) cytokine response, this model has not been as clearly established in humans. In addition, this current review of over 50 studies in humans suggests that age-associated changes in cytokine production are not consistent.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Shearer G.M. Th1/Th2 changes in aging. Mech. Ageing Develop. 1997;94:1–5. doi: 10.1016/S0047-6374(96)01849-0. - DOI - PubMed
    1. Hobbs M.V., Weigle W.O., Noonan D.J., Torbett B.E., McEvilly R.J., Koch R.J., et al. Patterns of cytokine gene expression by CD4+ T cells from young and old mice. J. Immunol. 1993;150:3602–3614. - PubMed
    1. Albright J.W., Zuiga-Pflcker J.C., Albright J.F. Transcriptional control of I L-2 and IL-4 in T cells of young and old mice. Cell. Immunol. 1995;164:170–175. doi: 10.1006/cimm.1995.1158. - DOI - PubMed
    1. Hobbs M.V., Weigle W.O., Ernst D. Interleukin-10 production by splenic CD4+ cells and cell subsets from young and old mice. Cell. Immunol. 1994;154:264–272. doi: 10.1006/cimm.1994.1076. - DOI - PubMed
    1. Adibzadeh M., Pohla H., Rehbein A., Pawelec G. Long-term culture of monoclonal human T lymphocytes: models for immunosenescence? Mech. Ageing Develop. 1995;83:171–183. doi: 10.1016/0047-6374(95)01625-A. - DOI - PubMed