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. 2013:2013:536231.
doi: 10.1155/2013/536231. Epub 2013 Mar 27.

Inclusion-body myositis associated with Alzheimer's disease

Danijela Levacic  1 , Leema Reddy Peddareddygari, David Nochlin, Leroy R Sharer, Raji P Grewal
Affiliations

Inclusion-body myositis associated with Alzheimer's disease

Danijela Levacic et al. Case Rep Med. 2013.

Abstract

Sporadic inclusion-body myositis (s-IBM) is a myopathy that is characterized by progressive weakness and muscle pathology demonstrating inflammation and rimmed vacuoles. In addition, similar to the pathology observed in the brains of patients with Alzheimer's disease, the deposition of beta-amyloid and phosphorylated tau proteins in muscle fibers has been reported. These shared pathologic features have prompted hypotheses suggesting a shared etiology of these two conditions. We report a case of a 73-year-old woman initially diagnosed with s-IBM who later developed Alzheimer's disease.

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Figures

Figure 1
Figure 1
(a) Muscle fiber showing rimmed vacuoles (granular, red) (long arrows), and fiber splitting (short arrow). (b) Muscle fiber showing slit-like rimmed vacuoles (Long arrows), with fiber splitting (short arrow). Histochemistry, section of anterior tibialis muscle stained with Engel's modified Gomori trichrome stain. Isopentane cooled in liquid nitrogen frozen section. 25× original magnification.
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References

    1. Dalakas MC. Sporadic inclusion body myositis—diagnosis, pathogenesis and therapeutic strategies. Nature Clinical Practice Neurology. 2006;2(8):437–447. - PubMed
    1. Roos PM, Vesterberg O, Nordberg M. Inclusion body myositis in Alzheimer's disease. Acta Neurologica Scandinavica. 2011;124(3):215–217. - PubMed
    1. Askanas V, Engel WK. Sporadic inclusion-body myositis and hereditary inclusion-body myopathies: diseases of oxidative stress and aging? Archives of Neurology. 1998;55(7):915–920. - PubMed
    1. Askanas V, Engel WK. Newest pathogenetic considerations in inclusion-body myositis: possible role of amyloid-beta, cholesterol, relation to aging and to Alzheimer's disease. Current Rheumatology Reports. 2002;4(5):427–433. - PubMed
    1. Askanas V, Engel WK. Sporadic inclusion-body myositis and its similarities to Alzheimer disease brain: recent approaches to diagnosis and pathogenesis, and relation to aging. Scandinavian Journal of Rheumatology. 1998;27(6):389–405. - PubMed

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