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. 2013 Mar 28:2013:840690.
doi: 10.1155/2013/840690. Print 2013.

Differences in the Characteristics of Barrett's Esophagus and Barrett's Adenocarcinoma between the United States and Japan

Makoto Oryu  1 , Hirohito Mori, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Mitsuyoshi Kobayashi, Mitsugu Yasuda, Tsutomu Masaki
Affiliations

Differences in the Characteristics of Barrett's Esophagus and Barrett's Adenocarcinoma between the United States and Japan

Makoto Oryu et al. ISRN Gastroenterol. .

Abstract

In Europe and the United States, the incidence of esophageal adenocarcinoma has increased 6-fold in the last 25 years and currently accounts for more than 50% of all esophageal cancers. Barrett's esophagus is the source of Barrett's adenocarcinoma and is characterized by the replacement of squamous epithelium with columnar epithelium in the lower esophagus due to chronic gastroesophageal reflux disease (GERD). Even though the prevalence of GERD has recently been increasing in Japan as well as in Europe and the United States, the clinical situation of Barrett's esophagus and Barrett's adenocarcinoma differs from that in Western countries. In this paper, we focus on specific differences in the background factors and pathophysiology of these lesions.

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Figures

Figure 1
Figure 1
(a) The esophagogastric junction was diagnosed in the upper end of the gastric fold and the lower end of the palisade vessels. Palisade vessels can be found in the Barrett esophagus. (b) Barrett esophagus by magnifying endoscpy and narrow band Imaging (NBI) observation.
Figure 2
Figure 2
Histopathological findings of the resected specimen (low-power view). Low-power view shows the remained squamous epithelium, specialized columnar epithelium, and esophageal gland or duct.
Figure 3
Figure 3
(a) Squamous columnar junction is located at 29 cm from the incisors. (b) Mucosal changes are seen in the entire circumference of pale redness and rough from squamous columnar junction to upper end of the gastric fold. (c) and (d) Endoscopic view revealed a reddish protruded lesion with an uneven surface located at 1 o'clock position in the oral side of Barrett's esophagus after the spreading of indigo carmine.
Figure 4
Figure 4
Histopathological findings of the resected specimen (low-power view). Pathological diagnosis shows Barrett's adenocarcinoma close to squamous epithelium.
See this image and copyright information in PMC

References

    1. Cameron AJ. Epidemiology of Barrett’s esophagus and adenocarcinoma. Diseases of the Esophagus . 2002;15:106–108. - PubMed
    1. Hongo M, Shoji T. Epidemiology of reflex disease and CLE in East Asia. Journal of Gastroenterology. 2003;38:25–30. - PubMed
    1. Sampliner RE. Practice guidelines on diagnosis, surveillance, and therapy of Barrett’s esophagus. The American Journal of Gastroenterology. 1998;93:1028–1032. - PubMed
    1. Vieth M, Aida J, Takubo K. Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma-reply. Human Pathology. 2009;40(8):1209–1210. - PubMed
    1. Playford RJ. New British Society of Gastroenterology (BSG) guidelines for the diagnosis and management of Barrett’s oesophagus. Gut. 2006;55(4):442–443. - PMC - PubMed

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